HYDROXYCITRIC ACID hplc
Hydroxy Citric Acid Potassium Salt
CAS: 6205-14-7
Molecular Formula: C6H8O8
HYDROXYCITRIC ACID hplc - Names and Identifiers
| Name | Hydroxy Citric Acid Potassium Salt |
| Synonyms | HAC HCA-K Hydroxycitric acid HYDROXYCITRIC ACID hplc Potassium Hydroxycitrate TRIPOTASSIUM-2-HYDROXYCITRATE Tripotassium-2-Hydroxycditracte 3-C-carboxy-2-deoxypentaric acid Hydroxy Citric Acid Potassium Salt Tripotassium-2-Hydroxycitrate(KHCA) HYDROXYCITRICACIDANDITSTRISODIUMSALT 1,2-Dihydroxy-1,2,3-propanetricarboxylic acid N~3~-cyclohexyl-2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)-N~7~-[3-(methylsulfanyl)phenyl]-1-oxo-1,2,3,6,7,7a-hexahydro-3a,6-epoxyisoindole-3,7-dicarboxamide |
| CAS | 6205-14-7 |
| EINECS | 1312995-182-4 |
| InChI | InChI=1/C32H35N3O6S/c1-42-22-11-7-10-20(16-22)34-29(36)26-25-14-15-32(41-25)27(26)31(38)35(28(32)30(37)33-19-8-3-2-4-9-19)17-21-18-39-23-12-5-6-13-24(23)40-21/h5-7,10-16,19,21,25-28H,2-4,8-9,17-18H2,1H3,(H,33,37)(H,34,36) |
HYDROXYCITRIC ACID hplc - Physico-chemical Properties
| Molecular Formula | C6H8O8 |
| Molar Mass | 208.12 |
| Density | 1.947±0.06 g/cm3(Predicted) |
| Boling Point | 393.3±42.0 °C(Predicted) |
| Flash Point | 485.2°C |
| Solubility | Chloroform, dichloromethane, ethyl acetate, DMSO, acetone, etc. |
| Vapor Presure | 2.13E-31mmHg at 25°C |
| Appearance | Powder |
| pKa | 2.90±0.28(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.676 |
| MDL | MFCD02093093 |
| Use | Used as a potassium supplement |
HYDROXYCITRIC ACID hplc - Reference Information
| Plant Source: | Garcinia Garcinia |
| Overview | hydroxycitric acid ((-)-HCA) is an important organic acid, which is a derivative of citric acid, in natural hibiscus plants have a lot of contains, its molecular formula is C6H8O8, it is composed of polyhydric alcohols and polybasic acids of high activity molecules, both can be prepared in the unit of high content of calcium salts, potassium salts and other health care products, the Multi-Active functional group can be used as a prodrug intermediate of some new drugs, and non-toxic special plasticizer and other fine chemical products can be prepared by esterification reaction. |
| Source | Garcinia cambogia, Garcinia, Garcinia, Garcinia, Garcinia, Garcinia, Garcinia, Garcinia, Garcinia, Garcinia, Garcina, etc, in the shell of the fruits of Garcinia indica and Garcinia atroviridis. The fruit shells of these plants, which are often used instead of tamarind or lemon as a flavoring and flavoring agent for Curry, are also used as preservatives and herbal tonic, etc. In addition, hydroxycitric acid is also present in the genus Hibiscus. Figure 1: Garcinia Garcinia |
| synthesis method | The synthesis method uses citric acid as a raw material, dehydrates to prepare aconitic acid, and then oxidizes the aconitic acid to prepare hydroxycitric acid. The optimal process conditions of aconitic acid and hydroxycitric acid were studied respectively. The optimal process conditions of aconitic acid were as follows: 1 mol of hydroxycitric acid was reacted with 56% sulfuric acid 270 mol at 140 ℃ for 7H, the melting point of aconitic acid is 186 ℃, and the waste acid and undecomposed citric acid are recycled. The recovery rate of citric acid and concentrated sulfuric acid is 28% and 65% respectively. The optimum conditions of hydroxycitric acid were as follows: the ratio of n oxidant to n aconitic acid was 2 ∶ 1, the reaction time was 16 h, the reaction temperature was 50 ℃, the yield of hydroxycitric acid was about 80%. Figure 2: Process Diagram for synthesis of hydroxycitric acid |
| physiological function | studies have shown that (-)-HCA can not only inhibit the synthesis of fatty acids and fats, it can also reduce appetite and food intake, and ultimately play a role in reducing body weight. In addition,(-)-HCA also has a good effect on appetite control. 5-hydroxytryptamine (5-HT) is a necessary neurotransmitter for many behavioral functions (such as mood, sleep and appetite control), which can affect the body's feeding behavior and body weight. If the body serum 5-HT level increases, it will also appear to reduce food intake, weight loss and increased energy consumption. (-)-HCA can significantly inhibit the reabsorption of 5-HT, and increase the level of serum 5-HT. |
| mechanism of action | citrate lyase catalyzes the cleavage of extra-mitochondrial citrate to oxaloacetate and acetyl-CoA. Citrate lyase is widely distributed in animal tissues and is believed to play a role in the conversion of carbohydrates to fats and gluconeogenesis. (-)-HCA can inhibit the cleavage of citric acid into oxaloacetate and acetyl-Co A outside the mitochondria by inhibiting the activity of citrate lyase, where acetyl-Co A is A molecule that plays A key role in the process of energy storage as fat.. Moreover,(-)-HCA may only act at a certain metabolic level and not act directly on the central nervous system as typical appetite suppressants do, therefore, pre-ingested (-)-HCA, and in the body to absorb nutrients (posta-bsorptively) after aerobic exercise, can enhance the role of new sugar, and help to improve endurance. Moreover, carnitine and bioactive chromium may also contribute to the enhancement of this endurance-enhancing effect of (-)-HCA. |
| safety toxicology | animal experiments showed that the toxicity of (-)-HCA was not stronger than that of citric acid. Citric acid is a compound contained in normal cells and is also used in many foods. (-)-HCA is a natural plant ingredient that is also used in cooking foods and medicines in India. Experiments have shown that a dose of 5000mg/kg body weight of (-)-HCA does not cause any visible signs of toxicity or death in experimental animals. This dose is approximately equivalent to a person's intake of 1.5g, or 233 times the average possible intake of g/d. (-)-HCA is not suitable for some people. Since (-)-HCA affects the synthesis of fatty acids and cholesterol in the body, it may directly affect the production of sterols and limit the production of sterol hormones. Women are very sensitive to sterol hormones during pregnancy and are therefore not suitable for consumption of (-)-HCA at this time. Similarly, breastfeeding women should also avoid (-)-HCA. There is also a view that although the promotion effect of HCA on gluconeogenesis and ketogenesis is not beneficial to diabetics, the good weight loss effect of HCA on obese non-insulin-dependent diabetics exceeds its negative effect, The advantages outweigh the disadvantages. In addition, although long-term consumption of fruits rich in (-)-HCA has not been shown to cause any harm to children, it is still recommended that children not consume too much (-)-HCA for a long time. |
| references | [1] Chen Li, Qin Jidong, He shengfen. Synthesis of hydroxycitric acid [J]. Journal of Nanjing University of Science and Technology (Natural Science Edition), 2001, 25(3):282-285. [2] Yuan Erdong. Research progress of functional active ingredient-hydroxycitric acid [J]. Food and Fermentation Technology, 2006, 42(2):19-23. [3] Zhao Xirong. Sources, preparation methods and properties of hydroxycitric acid [J]. China food additive, 2004(4):59-63. [4] Zhang Bo. Determination of hydroxycitric acid in functional foods by liquid chromatography [D]. Tianjin University, 2012. |
| Use | for potassium supplement |
Last Update：2024-04-09 20:45:29
Supplier List
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hydroxy Citric Acid Potassium Salt Request for quotationCAS: 6205-14-7
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: Hydroxy Citric Acid Potassium Salt Request for quotation
CAS: 6205-14-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 6205-14-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Hydroxy Citric Acid Potassium Salt Request for quotationCAS: 6205-14-7
Tel: 86+027-83389957
Email: 1024042217@qq.com
Mobile: 86+18627766980
QQ: 1024042217
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Product Name: Hydroxy Citric Acid Potassium Salt Request for quotation
CAS: 6205-14-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 6205-14-7
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Spot supply
Product Name: Hydroxycitric acid Visit Supplier Webpage Request for quotationCAS: 6205-14-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
HYDROXYCITRIC ACID hplc
PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
S-TRITYL-BETA-MERCAPTOPROPIONIC ACID
1-[(4-甲基苯基)磺酰基]-D-脯氨酸
N-OCTADECYLDIMETHYL(3-SULFOPROPYL)AMMONIUM HYDROXIDE
6β-羟基可的松
L-1-TOSYLAMIDE-2-PHENYLETHYL-CHLOROMETHYL KETONE
4-[(三甲基硅基)乙炔基]吡啶-2-胺
2-((2-氟苄基)氧基)-3-甲氧基苯甲醛
叔丁基2 - ((1H-吡咯并[2,3-B]吡啶-5-基)氧基)-4-溴苯甲酸酯
PGLU-GLY-PRO-TRP-LEU-GLU-GLU-GLU-GLU-GLU-ALA-TYR-GLY-TRP-LEU-ASP-PHE-NH2
S-TRITYL-BETA-MERCAPTOPROPIONIC ACID
1-[(4-甲基苯基)磺酰基]-D-脯氨酸
N-OCTADECYLDIMETHYL(3-SULFOPROPYL)AMMONIUM HYDROXIDE
6β-羟基可的松
L-1-TOSYLAMIDE-2-PHENYLETHYL-CHLOROMETHYL KETONE
4-[(三甲基硅基)乙炔基]吡啶-2-胺
2-((2-氟苄基)氧基)-3-甲氧基苯甲醛
叔丁基2 - ((1H-吡咯并[2,3-B]吡啶-5-基)氧基)-4-溴苯甲酸酯